Direct consequences of the fact that DNA molecules store and transfer genetic information are that lesions sustained by cellular DNA inevitably result in information loss and that error-free repair of ...
Poly ADP-ribose polymerase inhibitors (PARPi) are used for patients with advanced prostate cancer bearing alterations in homologous recombination repair (HRR) genes. We sought to characterize HRR gene ...
Recombination between homologous chromosomes is essential for successful meiosis. It drives genetic diversity in germline cells and provides the necessary scaffolding for accurate, balanced ...
Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a ...
A recent study, undertaken by researchers at the Tokyo Metropolitan University and the Tokyo Metropolitan Institute of Medical Science (both Japan), unravels key steps in the process of homologous ...
The discovery of synthetic lethality between BRCA mutations and PARP inhibitors ranks has led to major advances in the treatment of BRCA-mutated cancers. Mutations in BRCA1 and BRCA2 can leave cells ...
On any given day, our DNA takes a lot of damage. In a single cell, as many as 10,000 errors or lesions in our chromosomes can arise in the course of 24 hours. Most are accurately repaired, so the cell ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results